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|Juventus' Emre Can (rear centre) celebrates with teammates after scoring against Sassuolo during the Italian Serie A football match. (MIGUEL MEDINA/AFP)|
Ronaldo proved decisive, scoring after 70 minutes as Sami Khedira found the net first in Modena with fellow German Emre Can slotting in the third four minutes from time.
The Serie A champions had been held by Parma last week despite the Portugese forward's double.
Now they have left second-placed Napoli trailing after Carlo Ancelotti's side were held to a goalless draw at Fiorentina on Saturday.
Paulo Dybala again started on the bench coming on late for the champions, to help set up the third goal, with coach Massimiliano Allegri saying he needed to find the right balance.
"Ronaldo and Dybala can certainly play together and they will do, but we need everyone to work hard in order to keep the team balanced," said Allegri.
"It all depends on who you are playing against. Sassuolo have a strong midfield, so I had to balance my team that way today.
"Players are disappointed, but every now and then sitting on the bench is necessary to recharge batteries and rediscover the right mental toughness."
Juventus had started slowly with goalkeeper Wojciech Szczesny saving twice in the opening minutes as the champions were without injured defenders Leonardo Bonucci and Giorgio Chiellini.
The pair are fighting to be fit for Juventus's Champions League last 16 trip to Atletico Madrid in 10 days' time.
Juventus broke through after Sassuolo goalkeeper Andrea Consigli rushed out to parry a Ronaldo shot leaving the way clear for Khedira to turn in the rebound after 23 minutes.
It was the German international's second league goal of his injury-hit campaign, after scoring the opening goal of the Serie A season against Chievo on Aug 18.
Consigli denied Federico Bernardeschi just before the break with a Khedira header flying wide.
But Portuguese star Ronaldo jumped highest after 70 minutes to meet Pjanic's corner for his fourth goal in his last three league games to bring his tally to 20 goals for Juventus in all competitions.
The 34-year-old celebrated by mimicking Dybala's 'mask' goal celebration.
Argentine Dybala came off the bench seven minutes from time along with Can and was involved in the buildup for the final goal with Ronaldo proving the assist.
CHAMPIONS LEAGUE BATTLE TIGHT
Inter Milan are third - 20 points behind Juventus - after beating promoted Parma 1-0 on Saturday, for their first league win of 2019.
But city rivals AC Milan are just four points behind Inter in fourth after beat struggling Cagliari 3-0, with new signings Lucas Paqueta and Krzysztof Piatek both scoring.
Cagliari defender Luca Ceppitelli gave the hosts their first with an unfortunate own goal after 12 minutes.
Brazilian Paqueta volleyed in the second after 22 minutes with Polish forward Piatek again finding the net after 62 for his fourth goal in all competitions.
Paqueta dedicated his first goal in Italy to the ten victims of the fire that ripped through buildings at Rio club Flamengo, where he started his career.
"It was a very difficult time for me," said the 21-year-old.
"I am living a dream playing for Milan and scoring my first Serie A goal, but it was also a dream for me to be in the Flamengo youth academy and I can't forget those who were experiencing the same thing."
The battle for Europe remains tight with Atalanta, Roma and Lazio all just a point behind AC Milan.
The side from Bergamo battled to a 2-1 win over SPAL, with Roma beating Chievo 3-0 and Lazio seeing off Empoli 1-0 during the week.
"I've liked the team for a while now," said coach Gennaro Gattuso.
"Milan haven't fought for many years for a place in the Champions League, now we are here we need to work to stay."
Italian Serie A results:
Bologna 1 Genoa 1
Atalanta 2 SPAL 1
Sampdoria 0 Frosinone 1
Torino 1 Udinese 0
Sassuolo 0 Juventus 3
AC Milan 3 Cagliari 0