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|Liverpool defender Trent Alexander-Arnold has withdrawn from the England squad. (AFP/Paul ELLIS)|
Alexander-Arnold had been struggling with the problem before linking up with England and on Wednesday it was decided the right-back wouldn't recover in time to feature against the Czech Republic and Montenegro.
The 20-year-old has returned to Liverpool to continue treatment on the injury with a view to featuring for the Premier League leaders after the international break.
"Trent Alexander-Arnold has withdrawn from the England squad and returned to Liverpool," a Football Association statement read.
"The right-back arrived nursing a back injury and, despite progress in recent days, it was unlikely he would be able to play a role in the forthcoming UEFA EURO 2020 qualifiers.
"The 20-year-old will now continue his rehabilitation at his club leaving Gareth Southgate with a 22-man squad."
World Cup semi-finalists England host the Czech Republic in their opening qualifier at Wembley on Friday before travelling to Montenegro for the second Group A match on Monday.
Manchester City's Kyle Walker and Tottenham's Kieran Trippier are the other specialist right backs in the squad.
Alexander-Arnold is the fifth player to pull out of the England squad after Fabian Delph, John Stones, Luke Shaw and Ruben Loftus-Cheek.