"In the second half of 2010 a total of 364,102 counterfeit euro banknotes were withdrawn from circulation," a decline of 5.9 per cent, an ECB statement said.
That fall followed a drop of 13 per cent in the first half of the year to 387,000 bills, the first six-month decline since late 2006.
With the seized fake notes representing around just one in 37,350 in circulation "the proportion of counterfeits remains very low," the ECB said.
In 2007, total seizures had amounted to 561,000 banknotes, a small decline from 565,000 one year earlier.
The fake banknote most often seized remained the 50 euro ($67) bill this time around, with 43.5 per cent of the total, followed by the 20 euro note, at 38 per cent, the ECB said.
What the stars mean:
★ Poor ★ ★ Promising ★★★ Good ★★★★ Very good ★★★★★ Exceptional